Åke Borg
Principal investigator
Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies
Author
Summary, in English
A recent report estimated the breast cancer risks in carriers of the three Ashkenazi founder mutations to be higher than previously published estimates derived from population based studies. In an attempt to confirm this, the breast and ovarian cancer risks associated with the three Ashkenazi founder mutations were estimated using families included in a previous meta-analysis of populatrion based studies. The estimated breast cancer risks for each of the founder BRCA1 and BRCA2 mutations were similar to the corresponding estimates based on all BRCA1 or BRCA2 mutations in the meta-analysis. These estimates appear to be consistent with the observed prevalence of the mutations in the Ashkenazi Jewish population.
Department/s
- Breastcancer-genetics
Publishing year
2005
Language
English
Pages
602-603
Publication/Series
Journal of Medical Genetics
Volume
42
Issue
7
Document type
Journal article
Publisher
BMJ Publishing Group
Topic
- Medical Genetics
Status
Published
ISBN/ISSN/Other
- ISSN: 0022-2593