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Åke Borg

Åke Borg

Principal investigator

Åke Borg

Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer

Author

  • Christer Larsson
  • Anna Ehinger
  • Sofia Winslow
  • Karin Leandersson
  • Marie Klintman
  • Ludvig Dahl
  • Johan Vallon-christersson
  • Jari Häkkinen
  • Cecilia Hegardt
  • Jonas Manjer
  • Lao Saal
  • Lisa Rydén
  • Martin Malmberg
  • Åke Borg
  • Niklas Loman
Show all

Summary, in English

The extent and composition of the immune response in a breast cancer is one important prognostic factor for the disease. The aim of the current work was to refine the analysis of the humoral component of an immune response in breast tumors by quantifying mRNA expression of different immunoglobulin classes and study their association with prognosis. We used RNA-Seq data from two local population-based breast cancer cohorts to determine the expression of IGJ and immunoglobulin heavy (IGH) chain-encoding RNAs. The association with prognosis was investigated and public data sets were used to corroborate the findings. Except for IGHE and IGHD, mRNAs encoding heavy chains were generally detected at substantial levels and correlated with other immune-related genes. High IGHG1 mRNA was associated with factors related to poor prognosis such as estrogen receptor negativity, HER2 amplification, and high grade, whereas high IGHA2 mRNA levels were primarily associated with lower age at diagnosis. High IGHA2 and IGJ mRNA levels were associated with a more favorable prognosis both in univariable and multivariable Cox models. When adjusting for other prognostic factors, high IGHG1 mRNA levels were positively associated with improved prognosis. To our knowledge, these results are the first to demonstrate that expression of individual Ig class types has prognostic implications in breast cancer.

Department/s

  • LUCC: Lund University Cancer Centre
  • Tumor Cell Biology
  • Division of Translational Cancer Research
  • Pathology, Lund
  • Cancer Immunology, Malmö
  • Breastcancer
  • Breastcancer-genetics
  • Surgery
  • EpiHealth: Epidemiology for Health
  • Transl oncogenomics
  • Translational Oncogenomics
  • Breast cancer treatment
  • The Liquid Biopsy and Tumor Progression in Breast Cancer
  • Breast Cancer Surgery
  • Surgery (Lund)
  • Clinical Sciences, Helsingborg
  • Familial Breast Cancer
  • Breast/ovarian cancer

Publishing year

2020-07-06

Language

English

Publication/Series

npj Breast Cancer

Volume

6

Issue

1

Document type

Journal article

Publisher

Nature Publishing Group

Topic

  • Cancer and Oncology

Status

Published

Project

  • Sweden Cancerome Analysis Network - Breast (SCAN-B): a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine

Research group

  • Tumor Cell Biology
  • Cancer Immunology, Malmö
  • Surgery
  • Translational Oncogenomics
  • The Liquid Biopsy and Tumor Progression in Breast Cancer
  • Breast Cancer Surgery
  • Familial Breast Cancer

ISBN/ISSN/Other

  • ISSN: 2374-4677