Nonsense Mutations in the Shelterin Complex Genes ACD and TERF2IP in Familial Melanoma.
- Oncology and Pathology, MV
- Cancer Epidemiology
- Surgery (Lund)
Publishing year: 2015
Publication/Series: Journal of the National Cancer Institute
Document type: Journal article
Publisher: Oxford University Press
The shelterin complex protects chromosomal ends by regulating how the telomerase complex interacts with telomeres. Following the recent finding in familial melanoma of inactivating germline mutations in POT1, encoding a member of the shelterin complex, we searched for mutations in the other five components of the shelterin complex in melanoma families.
- Cancer and Oncology
- ISSN: 1460-2105