Åke Borg
Principal investigator
HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5
Author
Summary, in English
We previously reported that the human HER2 gene encodes the intronic microRNA mir-4728, which is overexpressed together with its oncogenic host gene and may act independently of the HER2 receptor. More recently, we also reported that the oncogenic miR-21-5p is regulated by 3′ tailing and trimming by the non-canonical poly(A) polymerase PAPD5 and the ribonuclease PARN. Here we demonstrate a dual function for the HER2 locus in upregulation of miR-21-5p; while HER2 signalling activates transcription of mir-21, miR-4728-3p specifically stabilises miR-21-5p through inhibition of PAPD5. Our results establish a new and unexpected oncogenic role for the HER2 locus that is not currently being targeted by any anti-HER2 therapy.
Department/s
- Breastcancer-genetics
- Cancer and non coding RNA
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Create Health
Publishing year
2016-10-18
Language
English
Publication/Series
Scientific Reports
Volume
6
Document type
Journal article
Publisher
Nature Publishing Group
Topic
- Cancer and Oncology
- Cell and Molecular Biology
Status
Published
Research group
- Cancer and non coding RNA
ISBN/ISSN/Other
- ISSN: 2045-2322