Åke Borg
Principal investigator
Correlation between estradiol-17 beta and progesterone cytosol receptor concentration, histologic differentiation and 3H-thymidine incorporation in endometrial carcinoma
Author
Summary, in English
Women treated with estrogen exhibit a higher risk of developing endometrial cancer. steroid hormones exert their effects on target tissue through specific cytosol receptor protein. Knowledge of this steroid receptor concentration in endometrial carcinoma might facilitate the treatment of recurrences. We have compared the concentrations of endometrial estrogen and progesterone cytosol receptors with the histologic grade of endometrial carcinoma as well as the rate of 3H-thymidine incorporation. We found a significant difference in receptor concentration between well-moderately differentiated tumours and poorly differentiated ones. No correlation was found between 3H-thymidine incorporation rate and differentiation. A positive correlation between thymidine incorporation rate and progesterone receptor concentration was noticed. The concentration of receptors varies within a wide range of each group of differentiation; thus 23% and 4% of the poorly differentiated tumours had higher concentration of estradiol and progesterone receptors respectively than the median values for well differentiated tumours.
Department/s
- Obstetrics and Gynaecology (Lund)
- Tumor microenvironment
- Breastcancer-genetics
- Familial Breast Cancer
- Personalized Breast Cancer Treatment
Publishing year
1982-07-01
Language
English
Pages
7-203
Publication/Series
Anticancer research
Volume
2
Issue
4
Document type
Journal article
Publisher
International Institute of Cancer Research
Topic
- Cancer and Oncology
Keywords
- Cytosol/analysis
- Female
- Humans
- Receptors, Estradiol
- Receptors, Estrogen/analysis
- Receptors, Progesterone/analysis
- Thymidine/metabolism
- Tritium
- Uterine Neoplasms/analysis
Status
Published
Research group
- Familial Breast Cancer
- Personalized Breast Cancer Treatment
ISBN/ISSN/Other
- ISSN: 0250-7005