Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Identification of TP53 gene mutations in uterine corpus cancer with short follow-up

Author:
  • Anjila Koul
  • Åke Borg
  • Tanja Pejovic
  • Pär-Ola Bendahl
  • Thomas Högberg
  • Constantin Iosif
  • Dick Killander
Publishing year: 1997
Language: English
Pages: 295-302
Publication/Series: Gynecologic Oncology
Volume: 67
Issue: 3
Document type: Journal article
Publisher: Academic Press

Abstract english

The involvement of the TP53 tumor suppressor gene in uterine corpus cancer was investigated by single-stranded conformation polymorphism and sequence analysis of its exons 4 to 10. Mutations were found in 12 (18.5%) of 65 cases. Ten of these 12 were single-base substitutions (8 missense and 2 nonsense mutations), whereas 2 were frame-shifting mutations. TP53 gene mutations correlated significantly with advanced surgical stage of disease (P = 0.006) and unfavorable tumor histology types (P = 0.003), whereas the association to myometrial wall invasion did not reach statistical significance (P = 0.054). TP53 gene mutations also correlated significantly with allelic loss at TP53 locus (P = 0.024), absence of estrogen (P = 0.045) and progesterone receptors (P = 0.001), DNA nondiploidy (P = 0.002), and high S-phase fraction values (P = 0.002). Our results suggest that inactivation of the TP53 checkpoint function is associated with disease transition into a stage of rapid progression and spread.

Keywords

  • Obstetrics, Gynecology and Reproductive Medicine
  • Cancer and Oncology
  • TP53
  • mutation
  • uterine corpus cancer
  • DNA ploidy

Other

Published
  • ISSN: 1095-6859
Åke Borg
Åke Borg
E-mail: ake.borg [at] med.lu.se

Principal investigator

Oncology and Pathology, MV

+46 46 275 25 52

MV 404 C21B2

90

Project manager

Familial Breast Cancer

90

Professor

Oncology and Pathology, MV

MV 404 C21C2

90