Åke Borg
Principal investigator
Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays
Author
Summary, in English
We present a strategy for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome single nucleotide polymorphism genotyping data. Using a dilution series of a tumor cell line mixed with its paired normal cell line and data generated on Affymetrix and Illumina platforms, including paired tumor-normal samples and tumors characterized by fluorescent in situ hybridization, we demonstrate a high sensitivity and specificity of the strategy for detecting both minute and gross allelic imbalances in heterogeneous tumor samples.
Department/s
- Breastcancer-genetics
- Division of Clinical Genetics
- Stem Cell Center
Publishing year
2008
Language
English
Publication/Series
Genome Biology
Volume
9
Issue
9
Document type
Journal article
Publisher
BioMed Central (BMC)
Topic
- Cancer and Oncology
- Medical Genetics
- Hematology
Status
Published
ISBN/ISSN/Other
- ISSN: 1474-7596