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Åke Borg

Åke Borg

Principal investigator

Åke Borg

Chromosome aberrations in prophylactic mastectomies from women belonging to breast cancer families

Author

  • C Petersson
  • N Pandis
  • F Mertens
  • A Adeyinka
  • C Ingvar
  • A Ringberg
  • I Idvall
  • L Bondeson
  • A Borg
  • Håkan Olsson
  • U Kristoffersson
  • F Mitelman
Show all

Summary, in English

Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rearrangements of 1q. Two of them, one of which also displayed a 3p14 rearrangement, shared a breakpoint in 1q41. Both 1q41 and, in particular, 3p14 have been reported to be rearranged frequently in malignant breast proliferations. Whether alterations of genes in these bands are essential in mammary tumorigenesis and, if so, whether they are equally important in sporadic and in hereditary cases remains to be explored.

Department/s

  • Division of Clinical Genetics
  • Surgery (Lund)
  • Lund Melanoma Study Group
  • Surgery
  • Tumor microenvironment
  • Pathology, Malmö
  • Breastcancer-genetics

Publishing year

1996-07

Language

English

Pages

185-188

Publication/Series

Genes, Chromosomes and Cancer

Volume

16

Issue

3

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Cancer and Oncology
  • Medical Genetics

Keywords

  • Adult
  • Breast Neoplasms
  • Cells, Cultured
  • Chromosome Aberrations
  • Female
  • Genetic Diseases, Inborn
  • Humans
  • Hyperplasia
  • Karyotyping
  • Mastectomy
  • Middle Aged
  • Precancerous Conditions
  • Risk Factors
  • Case Reports
  • Journal Article
  • Research Support, Non-U.S. Gov't

Status

Published

Research group

  • Lund Melanoma Study Group
  • Surgery
  • Pathology, Malmö

ISBN/ISSN/Other

  • ISSN: 1045-2257